Current Landscape of Mirnas and TGF‐Β Signaling in Lung Cancer Progression and Therapeutic Targets

Hussen, Bashdar Mahmud and Saleem, Safeen Jasim and Abdullah, Snur Rasool and Mohamadtahr, Sayran and Hidayat, Hazha Jamal and Rasul, Mohammed Fatih and Taheri, Mohammad and Kiani, Arda (2023) Current Landscape of Mirnas and TGF‐Β Signaling in Lung Cancer Progression and Therapeutic Targets. Molecular and Cellular Probes, 72. p. 101929. ISSN 08908508

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Abstract

Lung cancer (LC) is the primary reason for cancer-associated fatalities globally. Due to both tumor-suppressing and tumor-promoting activities, the TGF-β family of growth factors is extremely essential to tumorigenesis. A non-coding single-stranded short RNA called microRNA (miRNA), which is made up of about 22 nt and is encoded by endogenous genes, can control normal and pathological pathways in various kinds of cancer, including LC. Recent research demonstrated that the TGF-β signaling directly can affect the synthesis of miRNAs through suppressor of mothers against decapentaplegic (SMAD)-dependent activity or other unidentified pathways, which could generate allostatic feedback as a result of TGF-β signaling stimulation and ultimately affect the destiny of cancer tissues. In this review, we emphasize the critical functions of miRNAs in lung cancer progression and, more critically, how they affect the TGF-β signaling pathway, and explore the role of both the TGFβ signaling pathway and miRNAs as potential therapeutic targets for improving the treatments of LC patients.

Item Type: Article
Uncontrolled Keywords: MiRNA, TGF-β signaling pathway, Hallmarks of cancer, Lung cancer (LC), Therapeutic target
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology
Divisions: Department of Biomedical Science > Research papers
Depositing User: ePrints Depositor
Date Deposited: 31 Oct 2024 13:25
Last Modified: 31 Oct 2024 13:25
URI: https://eprints.cihanuniversity.edu.iq/id/eprint/2490

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