Hussen, Bashdar Mahmud and Hidayat, Hazha Jamal and Abdullah, Snur Rasool and Mohamadtahr, Sayran and Rasul, Mohammad Fatih and Samsami, Majid and Taheri, Mohammad (2023) Role of Long Non-Coding Rnas and TGF-Β Signaling in the Regulation of Breast Cancer Pathogenesis and Therapeutic Targets. Cytokine, 170. ISSN 10434666
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Abstract
The cytokine known as transforming growth factor (TGF) is essential for cell development, differentiation, and apoptosis in BC. TGF-β dysregulation can either promote or inhibit tumor development, and it is a key signaling pathway in BC spread. A recently identified family of ncRNAs known as lncRNAs has received a great deal of effort and is an important regulator of many cellular processes, including transcription of genes, chromatin remodeling, progression of the cell cycle, and posttranscriptional processing. Furthermore, both TGF-β signaling and lncRNAs serve as important early-stage biomarkers for BC diagnosis and prognosis and also play a significant role in BC drug resistance. According to recent studies, lncRNAs can regulate TGF-β by modulating its cofactors in BC. However, the particular functions of lncRNAs and the TGF-β pathway in controlling BC progression are not well understood yet. This review explores the lncRNAs' functional properties in BC as tumor suppressors or oncogenes in the regulation of genes, with a focus on dysregulated TGF-β signaling. Further, we emphasize the functional roles of lncRNAs and TGF-β pathway in the progression of BC to discover new treatment strategies and better comprehend the fundamental cellular pathways.
Item Type: | Article |
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Uncontrolled Keywords: | Breast cancer, LncRNAs, TGF-β signaling, Drug resistance, Therapeutic targets. |
Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology |
Divisions: | Department of Medical Biochemical Analysis > Research papers |
Depositing User: | ePrints Depositor |
Date Deposited: | 05 Nov 2024 05:27 |
Last Modified: | 05 Nov 2024 05:27 |
URI: | https://eprints.cihanuniversity.edu.iq/id/eprint/2482 |