Studies on the Preparation and in Vitro - in Vivo Evaluation of Mucoadhesive Microspheres of Glycyrrhetinic Acid Isolated from Liquorice

Visht, Sharad Visht and T. Kulkarni, G. (2015) Studies on the Preparation and in Vitro - in Vivo Evaluation of Mucoadhesive Microspheres of Glycyrrhetinic Acid Isolated from Liquorice. Bangladesh Pharmaceutical Journal, 18 (1). pp. 30-37. ISSN 2408-8463

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Abstract

The present work deals with the formulation and evaluation of mucoadhesive microspheres containing
glycyrrhetinic acid. Mucoadhesive microspheres were prepared by single phase emulsification method and heat
stabilization method. Chemical stabilization appeared as fast and simple technique for producing glycyrrhetinic
acid loaded microspheres. Microspheres prepared by this method produced sufficient production yield, high drug
encapsulation efficiency and reproducibility. Among the different formulations, microspheres with drug - polymer
ratio of 1:1 (C1) was found to have the maximum mucoadhesive property as well as in vitro and in vivo drug
release property. Therefore, it could be considered as the best formulation.

Item Type:	Article
Uncontrolled Keywords:	Mucoadhesive, Microspheres, Glycyrrhetinic Acid, Chemical Stabilization, Polymer, Liquorice
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Department of Pharmacy > Research papers
Depositing User:	ePrints Depositor
Date Deposited:	11 Aug 2025 06:16
Last Modified:	11 Aug 2025 06:16
URI:	https://eprints.cihanuniversity.edu.iq/id/eprint/4067

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