Comparison of Emulsification and Ionic Gelation Method of Preparation of Mucoadhesive Microsphere

The purpose of this study was to prepare and characterize microspheres loaded by Aceclofenac. To achieve this goal
Chitosan and Sodium alginate microspheres loaded by Aceclofenac were prepared by emulsification and ionic
gelation methods. Morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. Microscopic evaluation of microspheres showed that microspheres were spherical in shape. The size analysis results indicated that size range varied from 1 to 13 µm. Encapsulation efficiency of microspheres was increased by increasing drug to polymer ratio. Drug release was found to be Zero order. In conclusion, microspheres loaded with Aceclofenac were prepared that could be used for control delivery of Aceclofenac.