Here is the phrase with each word capitalized: **Effects Of 6-Weeks Water-Based Intermittent Exercise With And Without Zingiber Officinale On Pro-Inflammatory Markers And Blood Lipids In Overweight Women With Breast Cancer**

Overweight and obesity is a risk factor for breast cancer. In contrast, physical
regular activity has been suggested to help increase the survival of individuals with breast
cancer. However, few studies have assessed effect of individually and combined Zingiber
officinale (as a anti-inflammatory factor) with water-based exercise on the pro-inflammatory
markers and blood lipid levels in overweight women with breast cancer and results have been
inconsistent. The aim of this study was to determine the individual and concomitant effect of
6-wks water-based exercise and oral Zingiber officinale supplement on the aforesaid markers
in overweight women with breast cancer. Forty women diagnosed with breast cancer(48±5.4
years, 76±9 kg, fat mass 41.8±4 %), volunteered to participate in the study. Subjects were
randomly assigned into four groups; placebo, water-based exercise, Zingiber officinale and
water-based exercise + Zingiber officinale groups. Subjects in the Zingiber officinale group
and the exercise training+ Zingiber officinale group orally received 4 capsules (each capsule
contained 750 mg), 7 days a week and for 6 weeks. The water-based exercise program were
collected at a progressive intensity and time, ranged from 50% to 75% of heart rate reserve, in
a pool with 15 meters width, 4 times a week for 6 weeks. Fasting blood sampling was
collected at the pretest and post-test. The Zingiber officinale supplementation and or the
water-base exercise resulted in a reduction of hs-CRP, IL-6 and TG, as compared to pretest.
However, the combined intervention (water-base exercise and Zingiber officinale) group
showed significantly a far better effect on the markers of pro-inflammatory and blood lipids,
as compared to the water-base exercise or Zingiber officinale supplement alone groups and
the age-matched placebo group. Our findings indicate a protective effect of the nondrug
strategies such as water-base exercise and anti-inflammatory herbal factors such as; Zingiber
officinale in the pathogenesis of inflammatory and metabolic responses in overweight women
diagnosed with breast cancer.