Interferon Gamma Levels in Relation to COVID-19 Vaccine

Abstract- One-hundred and twenty cases studied in this study
for whom they take vaccine dose or not, for infected and noninfected with coronavirus. They are classified to four groups (Covid-19 – Non-Vaccinated = CN); (Covid-19 – Vaccinated = CV); (Non Covid-19 – Non-Vaccinated = NN); (Non-Covid-19 – Vaccinated = NV) each group involved 30 cases. After withdrawing the blood from each person, the blood poured into two tube (5 ml to Gel tube and 2 ml to EDTA tube) and immunological parameters directly performed by hematological analyzer, while the serum, after centrifugation of blood and storing them in special tubes, used to estimation of IFN- γ by Enzyme Linked Immunosorbent Assay (ELIZA) and Lactate Dehydrogenase (LDH) by chemical analyzer. The study showed that there is a slight increasing in IFN- γ as proinflammatory cytokine and LDH concentration which related to the severity of the disease, while there is rising in WBC
number both vaccinated groups and cases with COVID-19
infection.