Some Hematological and Hormonal Parameters in Thyroid Dysfunction Patients

Thyroid hormones play a crucial role in regulating
metabolism and energy production. The cross-sectional study
aimed to determine some hematological and hormonal parameters
in thyroid dysfunctions patients. A total of 86 subjects were
included in the study and grouped into three groups depend on
thyroid stimulating hormone (TSH) concentration: Group 1 (12
healthy subjects as control), Group 2 (37 untreated hyperthyroid
patients),
Group 3 (Hypothyroid). Thyroid hormones,
hematological parameters and hormonal parameters such as
erythropoietin (EPO), leptin hormones and insulin-like growth
factor-1 (IGF-1) were measured.
The results of hematological analysis showed significant reduction
in mean cell volume (MCV), mean cell hemoglobin (MCH), red cell
distribution width (RDW) in hypothyroid patients as compared to
control group. Significant decrease was seen in MCV and MCH in
hypothyroidism patients as compared to hyperthyroidism
patients. The absolute value of granulocyte increased significantly
in hypothyroid patients as compared to hyperthyroid patients, but
this increase was not significant as compared to control.
Plateletcrit (PCT) significantly increased in hypothyroidism
patients when compared to control.
In conclusion this study revealed that serum erythropoietin (EPO)
was decreased significantly in both hyperthyroidism and
hypothyroidism compared to control. Moreover, significant
decrease was observed in serum leptin and insulin-like growth
factor-1 (IGF-1) in hypothyroidism patients as compared with
control subjects.