Elevation of IL-17 in Chronic Kidney Failure in Iraqi Patient

One of the most significant social health issues is
chronic kidney disease (CKD). The Republic Ministry of
Health/Environment reported that 6,879 persons died in 2015
from renal failure, placing chronic kidney disease (CKD) at
number five on the list of Iraq's most dangerous diseases.
Materials and Methods: This study included 60 cases that were
classified as 30 patients with chronic renal failure; these patients,
age range 30 – 59 years old were admitted from the Al-Karama
Teaching Hospital, Baghdad province, during the period from
December 2022 to January 2023 which they compared with 30
samples of healthy controls. For determining the IL-17 levels, the
researchers employed Enzyme-linked immunosorbent assay
(ELISA).
Results: It was found that most of the people who suffer from CKD
failure within the age group (40- 49) years that account (60%), and
most of these patients were females that constituted (59%). IL-17
serum level increases significantly (27.28 ±1.50) in chronic renal
patients compared to the control group (13.02 ±0.34).
Conclusion: Highly significant elevated pro-inflammatory
cytokines (IL-17) in chronic renal diseases indicate these cytokines
participate in the pathophysiology of reduced renal function and
the role of this cytokine as principal mediators of inflammatory
reaction in renal damage.