Influence of Interleukin-6 174G>C gene Polymorphism on Patients with Stable Coronary Artery Disease

Coronary artery disease is caused by
plaque buildup in the arteries' walls that deliver blood to the heart.
The study examined the correlation between the IL-6 gene
promoter 174G>C polymorphism, blood IL-6 levels, and specific
physiological parameters in Kurdish people from Iraq with stable
coronary artery disease (CAD).
Methods: The investigation took place on a sample of 62 persons
diagnosed with stable coronary artery disease (SCAD) and a
control group of 31 individuals without CAD. The Sanger
sequencing method was employed to detect IL-6 SNP genes, and
the enzyme-linked immunoassay (ELISA) was used to measure
serum IL-6 and A Cobas to evaluate serum biochemical variables.
Results: The prevalence of the wild homogeneous GG genotype
was lower in stable CAD patients compared to non-CAD
individuals with a major alteration, indicating its preventive role
against the development of the disease. The presence of GC+CC
genotypes has a more favorable effect on illness progression than
the dominant GG genotype. Additionally, the C allele was found
to be a risk factor for the disease. In the study, IL-6 showed strong
positive associations with RBC count, HCT, Granulocyte count,
WBC, PDW, ICAM1 levels, and OX-LDL. The stepwise
multivariate regression analysis revealed that Ox-LDL was crucial
in determining the serum IL-6 levels in individuals with stable
CAD. Additionally, MDA had a minor impact on the relationship
between total Ox-LDL and IL-6 levels, suggesting that there might
be a partial mediation effect.
Conclusions: the results for IL-6 indicate that the CC genotype
increases CAD risk, GG decreases this risk, and GC+CC
genotypes decrease the risk of CAD progression.