Cytotoxic Effect of Cassia Fistula Extracts Combined With Anticancer Drug on Human Colon Cancer Cells

According to scientific studies, combining particular antioxidants in set quantities with some chemotherapy treatments may increase therapeutic efficacy or lessen the severity of side effects. A pleiotropic phytochemical from the Fabacaceae family is called cassia fistula. Although, The current study evaluated the anticancer properties of Cassia fistula in combination with Cisplatin on the colorectal cancer cell line LS47T. LS47T colorectal cancer cells were exposed to C. f. extract, and the results showed that this drastically decreased cell viability in a dose and time dependent manner. Additionally, cells treated with 480 g/ml of Cassia fistula extract had lower viability. Treatment with 120 or 240 mg/kg C.f extract reduced tumor growth, according to in vivo experiments. Due to the study's results, cisplatin alone did not have the same therapeutic impact on colorectal cancer as a combination of plant extract and cisplatin. are required to determine the chemical makeup of the active substances. The findings of this study could aid in the creation of innovative and effective methods for treating colon cancer in humans.