Polycystic Ovary Syndrome Under TNF and TAC Regulation

Background: Polycystic Ovary Syndrome (PCOS) is a hormonal syndrome. One of an important disorder in women under physiological and immunological regulation. Affected by many factors and can diagnosis by many serological and immunological markers. Aim of study: Goal of present study target on tumor necrosis factor (TNF) and total antioxidant capacity (TAC) investigation. Methods: Current investigation involved 80 women (patients and control) with different ages from JANUARY 2022 to MARCH 2023 after recording information about patients. The cupric ion reduction antioxidant capacity (CUPRAC) method has been used to estimate TAC. ELISA test performed to evaluate TNF. Results: The highest percentage of disease was found in the age group [19-22]. It was the highest rate of 58%, followed by the age group [23-26] the lowest incidence rate in the age group [27-30] was 5%. According to location of patients in cities, varied between four cities included (Babylon, Karbala, Najaf and Baghdad) with a highest frequent showed in Babylon as (60%). Physiological study showed there are non-significant different between blood groups and PCOS under (P≤0.05), although varied the percentage in patients in four types (A+, B+, AB+ and O+) with highest percent in A+ about (38%). On other manner when measured total antioxidant capacity (TAC) also showed non-significant different between patients and control according to age group with a highest concentration in age group (19-22 y) in patients and control (3.7033± 0.8835 μm/l) (3.106± 0.427 μm/l) respectively. Immunological study, TNF concentration showed statistically significant difference (P≤0.05) in all age group compared to control with a highest level in (27-30y) as (170.207±3.68 pg/ml) for patients and (45.479±1.247 pg/ml) to control. Conclusion: The current study pointed about the correlation subject between TNF and TAC, results find there is an inverse correlation between them in patients’ group with present revers relationship in control group, that ensure an important of immune regulation. Those achieve the aim of our study.