Association Between Interleukin-17A and IL17F Gene Polymorphisms and the Development of Infertility in Kurdish Women

Background: Infertility is a medical disorder characterized by inability of a couple to conceive following a year of unprotected sexual activity. This study was aimed to demonstrate the serum interleukin-17 (IL-17A), IL-17F and demonstrate the role of IL-17A rs2275913 and IL-17F rs763780 single nucleotide polymorphism (SNPs) gene in the infertile Kurdish women. Methods: Using the enzyme-linked immunosorbent assay (ELISA), the serum IL-17A and IL-17F levels in 50 fertile participants and 134 women with infertility diagnoses were determined in this case-control research. The genotyping of the IL17A and IL-17F SNPs genes was found using the tetraamplification refractory mutation system-PCR (T-ARMS-PCR) technique. Results: Infertile women had a statistically significant lower serum concentration of IL-17A compared to fertile participants. Conversely, the serum level of IL-17F was non-significantly higher in infertile women compared to fertile women. In IL-17A, women with the AA genotype, recessive model (AA+GA) vs. GG, and A allele exhibited a higher risk for infertility. In the case of IL-17F, the TC and CC genotypes, and C allele, show a greater risk for infertility. Conclusions: The present study confirmed that IL-17A and IL17F gene polymorphisms were associated with an increased risk of women's infertility.