Immuno-Hematological Study of Cutaneous Leishmaniasis and the Role of Interleukin 8 in the Pathogenesis According to Sex in Babylon Governorate-Individuals

Using an immunological and hematological approaches, the leishmanial parasite strains were characterized, In comparison to control healthy groups (10.9 pg/ml), the mean concentration of the interleukin 8 (19.06 pg/ml) was considerably higher at the sera of patients suffering from cutaneous leishmaniasis. Patients with cutaneous leishmaniasis had higher levels of leukocytes, neutrophils and lymphocytes, and lower levels of hemoglobin and platelets. According to hematological investigations of Leishmania tropica and L. major are the two only known etiological agents of cutaneous leishmaniasis in the Babylon Governorate. In relation to ELISA-based detection of the disease. The sera from 41 patients and 31healthy donors were collected for assessment of IL-8 cncentration.The assessment of IL-8 serum levels was carried out by using two Elisa kits, IL-8 and CL (Ylbiont, china).The findings showed that individuals with cutaneous leishmaniasis had a significantly higher level of IL-8 (19.06 , pg/ml) than that of healthy control groups (10.9 pg/ml). In comparison to males (31.5 pg/ml) with cutaneous leishmaniasis, females had a lower level of IL-8 (26.58 pg/ml). Increased levels of IL-8 were found in the sera of cutaneous leishmaniasis-individuals, and according to this investigation. Ages and sexes of infected individuals with cutaneous leishmaniasis have correlated with levels of the interleukin 8. Aim of the study: The main purpose of the present study is to look at of the fundamental role of IL-8 in the pathogenesis of cutaneous leishmaniasis-infected individuals according to their sexes in the Babylon Governorate.