Enhanced Antibacterial Efficacy Through Piezo Memorial Effect of Catio3/Tio2 Nano-Composite

The expansion of new antibiotics or a new way to treat infections or prevention caused by drug-resistant Gram-negative and Gram-positive bacteria is of paramount importance as antibiotic resistance continues to increase worldwide. This study aimed to study the antibacterial piezo activity of CaTiO3/TiO2 nanocomposite and its antibacterial memorial effect against multi-drug resistance Gram-positive, including Staphylococcus aureus and Gram-negative bacteria, including Escherichia coli. We used the disk diffusion method modified Broth macrodilution antibacterial test to study the antibacterial effect. Our results show that CaTiO3/TiO2 nanocomposite exhibits an ∼100 % antibacterial ratio against S. aureus and E. coli after applying mechanical forces, it shows better performance compared to the Azithromycin. It shows antibacterial activity even 8 days after applying mechanical force. The antibacterial efficacy of the piezo CaTiO3/TiO2 nanocomposite against multidrug-resistant is particularly promising.