Qasim, Faroq Omer and Ameen, Ahmed Jaddo Mohamed and Qadirc, Kale Mohammed and Hamid, Mohammed A. and Yousif, NzarI. (2024) A Simple Stability-Indicating UV Spectrophotometric Method Developed and Validation for Detection of Paracetamol in (Liquid, Solid) Dosage form and Biological Fluid: Application and Comparison. Pakistan Journal of Life and Social Sciences (PJLSS), 22 (2). pp. 2838-2850. ISSN 17274915
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Abstract
A new stability indicating method UV-Vis Nanodrop 2000c has been developed and validated for detection of paracetamol (PCM) in (liquid, solid) dosage form and biological fluid. The maximum absorption of paracetamol was shown at 247 nm using methanol as solvent. The developed method was found to be linear R2 0.9999 within the concentration range from 0.2 to 30 μg/mL. High precision level % of RSD less than 1%. The LOD and LOQ values are 0.47 1.44 μg/mL, respectively. The accuracy and recovery of the method at three levels showed good results more than 100%± 0.5 with % RSD less than 2% and small percent of SEM. The proposed method was employed to assess the stability of both locally-produced and
commercially-available tablets. This research analyzed the stability of their drugs under various conditions, including heat, humidity, acidity, alkaline, oxidative, and photolytic conditions. The method was successfully verified in compliance with the requirements established by the International Council for Harmonization (ICH). Afterwards, the approved method was used to detection of PCM in pharmaceutical dosage forms that are commercially available.
Item Type: | Article |
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Uncontrolled Keywords: | Nanodrop 2000c, Spectrophotometer, Paracetamol, Validation, Degradation Study . |
Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
Divisions: | Department of Medical Laboratory Science > Research papers |
Depositing User: | ePrints Depositor |
Date Deposited: | 21 Nov 2024 12:41 |
Last Modified: | 21 Nov 2024 12:41 |
URI: | https://eprints.cihanuniversity.edu.iq/id/eprint/2879 |