Advanced Strategies of Targeting Circular RNAs as Therapeutic Approaches in Colorectal Cancer Drug Resistance

Hussen, Bashdar Mahmud and Abdullah, Snur Rasool and Mohammed, Abdulqahar Azizkhan and Rasul, Mohammed Fatih and Hussein, Ali M. and Eslami, Solat and Glassy, Mark C. and Taheri, Mohammad (2024) Advanced Strategies of Targeting Circular RNAs as Therapeutic Approaches in Colorectal Cancer Drug Resistance. Pathology - Research and Practice, 260. pp. 1-17. ISSN 03440338

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Abstract

Colorectal cancer (CRC) stands second in terms of mortality and third among the highest prevalent kinds of
cancer globally. CRC prevalence is rising in moderately and poorly developed regions and is greater in
economically advanced regions. Despite breakthroughs in targeted therapy, resistance to chemotherapeutics
remains a significant challenge in the long-term management of CRC. Circular RNAs (circRNAs) have been
involved in growing cancer therapy resistance, particularly in CRC, according to an increasing number of studies
in recent years. CircRNAs are one of the novel subclasses of non-coding RNAs, previously thought of as viroid.
According to studies, circRNAs have been recommended as biological markers for therapeutic targets and
diagnostic and prognostic purposes. That is particularly notable given that the expression of circRNAs has been
linked to the hallmarks of CRC since they are responsible for drug resistance in CRC patients; thereby, circRNAs
are significant for chemotherapy failure. Moreover, knowledge concerning circRNAs remains relatively unclear
despite using all these advanced techniques. Here, in this study, we will go over the most recent published work
to highlight the critical roles of circRNAs in CRC development and drug resistance and highlight the main
strategies to overcome drug resistance to improve clinical outcomes.

Item Type: Article
Uncontrolled Keywords: Circular RNAs (circRNAs), Colorectal Cancer (CRC), Drug Resistance
Subjects: Q Science > QR Microbiology
R Medicine > RG Gynecology and obstetrics
Divisions: Department of Biomedical Science > Research papers
Depositing User: ePrints Depositor
Date Deposited: 20 Nov 2024 17:27
Last Modified: 24 Nov 2024 13:32
URI: https://eprints.cihanuniversity.edu.iq/id/eprint/2728

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