Chemical Composition and In Vitro Evaluation of Antioxidant and Antiproliferative Effects of Volatile Oils Hydrodistilled from Onobrychis Carduchorum C.C. Towns., a Kurdish Traditional Plant

Amin, Hawraz Ibrahim M. and Abdoulrahman, Kamaran and Sadraddin, Azad S. and Smail, Heman A. and Jawhar, Zanko Hassan and Dilawer Issa, Kovan and Armijos, Chabaco and Vidari, Giovanni (2023) Chemical Composition and In Vitro Evaluation of Antioxidant and Antiproliferative Effects of Volatile Oils Hydrodistilled from Onobrychis Carduchorum C.C. Towns., a Kurdish Traditional Plant. Plants-Basel, 12 (16). pp. 1-13. ISSN 2223-7747

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Abstract

The volatile oils hydrodistilled from the aerial parts and roots of O. carduchorum C.C Towns. (Fabaceae) have been chemically characterized for the first time. A total of 43 constituents with an abundance >0.03% were identified and quantified in the two oils by GC/MS and GC/FID analyses. They comprise 38 components (98.58%) of the oil isolated from the aerial parts (OCA) and 34 components (93.33%) of the oil from the roots (OCR). Six constituents, α-pinene (23.11 ± 0.1%), β-elemene (17.33 ± 0.1%), 1,8-cineole (12.15 ± 0.2%), furfural (7.91 ± 0.1%), terpineol-4-ol (6.32 ± 0.2%), and limonene (4.13 ± 0.1%), accounted for about 75% of the total OCA oil. On the other hand, 1,8-cineole (15.79 ± 0.1%), furfural (10.44 ± 0.1%), β-elemene (10.14 ± 0.2%), α-terpineol (7.74 ± 0.1%), linalool (7.45 ± 0.1%), and α-pinene (4.76 ± 0.1%) made up about 60% of the OCR oil. The IC50 values of the scavenging activities of the OCA and OCR oils towards the DPPH radical and H2O2 were 79.8 ± 0.5 and 153.3 ± 0.6 μg/mL and 394.09 ± 0.2 and 311.67 ± 0.4 μg/mL, respectively. In addition, in the MTS assay, the OCA and OCR oils showed significant antiproliferative effects against T47D, MDA-MB-453, BG-1, and A549 human cancer cells that were more powerful than those against two normal human cell lines, HEK-293 and HFF-1. The abundant presence of β-elemene as an antiproliferative component of the two oils suggested the existence of a new chemotype of O. carduchorum.

Item Type: Article
Uncontrolled Keywords: Onobrychis Carduchorum; Fabaceae; Kurdish Traditional Medicine; Essential Oils; Antiradical; Antioxidant; Antiproliferative Effects; β-Elemene
Subjects: Q Science > QD Chemistry
Divisions: Department of Medical Biochemical Analysis > Research papers
Depositing User: ePrints Depositor
Date Deposited: 31 Oct 2024 12:11
Last Modified: 31 Oct 2024 12:11
URI: https://eprints.cihanuniversity.edu.iq/id/eprint/2439

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