Maximum Performance Of Neutralizing Antibodies Depends On Fc Function

"The viral pneumonia outbreak starting from the end of 2019, is becoming a global health issue.
Millions of infections and thousands of deaths are caused by a coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19.
Humoral immune responses associated with immune memory and the production of virus-
specific antibodies of the IgM, IgG, and IgA isotypes, play critical roles in antiviral immunity.
Neutralizing antibodies (NAbs) are also playing critical role in treatments of COVID-19.
Bioluminescence imaging (BLI ) and real-time monitoring of NAb treatment used to investigate this role. As long as virus spreads from nasal cavity to body, NAbs and Fc effector function require for prevention and treatment of infection. On the other hand, Monocytes, neutrophils and NK cells contribute to Fc- dependent NAb protection. As a conclusion Fab and Fc effector functions of NAbs crucial for in vivo efficacy against SARS-CoV-2."