A Review on the Role of FOXD2-AS1 in Human Disorders

Ghafouri-Fard, Soudeh and Harsij, Atefeh and Hussen, Bashdar Mahmud and Pourmoshtagh, Hasan and Taheri, Mohammad (2024) A Review on the Role of FOXD2-AS1 in Human Disorders. Pathology - Research and Practice, 254. p. 155101. ISSN 03440338

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Abstract

FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) is a long non-coding RNA being transcribed from a locus on chromosome 1p33. This transcript has been found to be up-regulated in tumor samples of almost all types of malignancies in association with a significant increase in malignant features. FOXD2-AS1 can affect activity of PI3K/AKT, AKT/mTOR, Hippo/YAP, Notch, NRf2, Wnt/β-catenin, NF-ƙB and ERK/MAPK pathways. Furthermore, it can enhance stem cell properties in cancer cells and prompt epithelial-mesenchymal transition. It is also involved in induction of resistance to a variety of anticancer agents such as adriamycin, cisplatin, 5-fluorouracil, temozolomide and gemcitabine. This article summarizes the impact of FOXD2-AS1 in diverse human disorders.

Item Type: Article
Uncontrolled Keywords: FOXD2-AS1, LncRNA , Cancer
Subjects: Q Science > QM Human anatomy
Divisions: Department of Biomedical Science > Research papers
Depositing User: ePrints Depositor
Date Deposited: 30 Oct 2024 12:18
Last Modified: 30 Oct 2024 12:19
URI: https://eprints.cihanuniversity.edu.iq/id/eprint/1872

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