The Intra Gastric Effects of Grape Juice on Histological Structure of Liver Tissue in Castrated Treated Mice

The effect of ingestion of freshly prepared ethanoic extract of grape juice was investigated on the histology of liver tissue on both castrated and castrated treated with 10 µl/g of grape juice. The histological sections of liver tissue from castrated group showed ballooning degeneration, macro and micro vesicular steatosis, lobular inflammation, hydropic degeneration, cellular inflammatory of lymphocytes and acidophil bodies (Councilman Body) as compared with the control group. The orally administration of 10µl/g grape juice for 6 weeks to castrated subjects was able to restore the histological structure of liver tissue to normal structure as compared with the control group. These results suggest that the fresh extract of grape juice can exert hepatoprotective effects of castration.