Homady, M. H and Juma, A. S. M and Ubeid, M. H (2021) Ultra Structural Studies of Mouse Liver in Castrated Subjects Treated with Grape Juice. International Journal of Clinical Case Reports and Reviews, 6 (3). pp. 1-5. ISSN 26904861
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Abstract
The present study was designed to evaluate the alterations in the liver tissues especially ITO and Kupffer cells of both castrated and castrated mice treated with10 µl/g of grape juice. The present study was conducted on forty five healthy males of Swiss albino mice, which were divided into 3 groups (N= 15 mice per each group). The first group was intact (control); the second one was castrated and the third group was castrated treated with 10 µl/g of grape juice. The ultra-structure sections of liver tissue from intact (control) group showed normal structure of both hepatocytes and sinusoids, with smooth external surfaces. Whereas ultra-sections from castrated group resulted in: degeneration of hepatocytes, deterioration of sinusoids; rough external surfaces, with aggregations of lipid droplets and white blood cells as compared with the control group. However treatment of castrated subject's with10µl/g of grape juice resulted in activation the regeneration processes in both hepatocytes and sinusoids, with smooth appearance of the external surfaces as compared with control group. The present study concluded that surgical castration aggravated increased hepatic steatosis and increased inflammatory response by increased activation of Kupffer and Ito cells, these effects could be reserved by aggravated increased grape juice administration.
Item Type: | Article |
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Uncontrolled Keywords: | liver; Castration; Grape juice; Kupffer cells; Scanning electron microscope |
Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
Divisions: | Department of Biomedical Science > Research papers |
Depositing User: | ePrints Depositor |
Date Deposited: | 09 Oct 2024 06:55 |
Last Modified: | 09 Oct 2024 06:55 |
URI: | https://eprints.cihanuniversity.edu.iq/id/eprint/1531 |