Mahal, Ahmed and Duan, Meitao and Zinad, Dhafer S. and Mohapatra, Ranjan K. and Obaidullah, Ahmad J. and Wei, Xiaoyi and Pradhan, Manoj K. and Das, Debadutta and Kandi, Venkataramana and Zinad, Hany S. and Zhu, Quanhong (2021) Recent Progress In Chemical Approaches For The Development Of Novel Neuraminidase Inhibitors. RSC Advances, 11 (3). pp. 1804-1840. ISSN 2046-2069
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Abstract
Influenza virus is the main cause of an infectious disease called influenza affecting the respiratory system including the throat, nose and lungs. Neuraminidase inhibitors are reagents used to block the enzyme called neuraminidase to prevent the influenza infection from spreading. Neuraminidase inhibitors are widely used in the treatment of influenza infection, but still there is a need to develop more potent agents for the more effective treatment of influenza. Complications of the influenza disease lead to death, and one of these complications is drug resistance; hence, there is an urgent need to develop more effective agents. This review focuses on the recent advances in chemical synthesis pathways used for the development of new neuraminidase agents along with the medicinal aspects of chemically modified molecules, including the structure–activity relationship, which provides further rational designs of more active small molecules.
Item Type: | Article |
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Uncontrolled Keywords: | Neuraminidase Inhibitors, Structure-Based Drug Design, SAR (Structure-Activity Relationship) Studies, Novel Chemotypes Small Molecule Inhibitors. |
Subjects: | Q Science > QR Microbiology > QR355 Virology |
Divisions: | Department of Medical Biochemical Analysis > Research papers |
Depositing User: | ePrints Depositor |
Date Deposited: | 07 Oct 2024 09:32 |
Last Modified: | 07 Oct 2024 09:32 |
URI: | https://eprints.cihanuniversity.edu.iq/id/eprint/1495 |