Inflammation, Immunity And Potential Target Therapy Of SARS-COV-2: A Total Scale Analysis Review

Smail, Shukur Wasman and Saeed, Muhammad and Alkasalias, Twana and Khudhur, Zhikal Omar and Younus, Delan Ameen and Rajab, Mustafa Fahmi and Abdulahad, Wayel Habib and Hussain, Hafiz Iftikhar and Niaz, Kamal and Safdar, Muhammad (2021) Inflammation, Immunity And Potential Target Therapy Of SARS-COV-2: A Total Scale Analysis Review. Food and Chemical Toxicology, 150. pp. 10-112087. ISSN 02786915

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Abstract

Coronavirus disease-19 (COVID-19) is a complex disease that causes illness ranging from mild to severe respiratory problems. It is caused by a novel coronavirus SARS-CoV-2 (Severe acute respiratory syndrome coronavirus-2) that is an enveloped positive-sense single-stranded RNA (+ssRNA) virus belongs to coronavirus CoV family. It has a fast-spreading potential worldwide, which leads to high mortality regardless of lows death rates. Now some vaccines or a specific drug are approved but not available for every country for disease prevention and/or treatment. Therefore, it is a high demand to identify the known drugs and test them as a possible therapeutic approach. In this critical situation, one or more of these drugs may represent the only option to treat or reduce the severity of the disease, until some specific drugs or vaccines will be developed and/or approved for everyone in this pandemic. In this updated review, the available repurpose immunotherapeutic treatment strategies are highlighted, elucidating the crosstalk between the immune system and SARS-CoV-2. Despite the reasonable data availability, the effectiveness and safety of these drugs against SARS-CoV-2 needs further studies and validations aiming for a better clinical outcome.

Item Type: Article
Uncontrolled Keywords: Coronavirus, Disease-19, Immunotherapeutic Drugs, Repurpose, Severe Acute Respiratory Syndrome coronavirus 2, Monoclonal, Antibodies, Vaccine
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
Q Science > QR Microbiology > QR355 Virology
Divisions: Department of General Biology > Research papers
Depositing User: ePrints Depositor
Date Deposited: 06 Oct 2024 12:41
Last Modified: 06 Oct 2024 12:41
URI: https://eprints.cihanuniversity.edu.iq/id/eprint/1420

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