Garcinia Mangostana Peel Extracts Exhibit Hepatoprotective Activity Against Thioacetamide-Induced Liver Cirrhosis In Rats

Abood, Walaa Najm and Bradosty, Sarwan W. and Shaikh, Faiyaz Khudaboddin and Salehen, Nur'Ain and Farghadani, Reyhaneh and Agha, Nabaz Fisal Shakir and Al-Medhtiy, Morteta H. and Kamil, Treska Dhia Aldeen and Agha, Ali Salim and Abdulla, Mahmood Ameen (2020) Garcinia Mangostana Peel Extracts Exhibit Hepatoprotective Activity Against Thioacetamide-Induced Liver Cirrhosis In Rats. Journal of Functional Foods, 74. pp. 1-11. ISSN 17564646

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Abstract

The study in vivo evaluated the influence of ethanolic extract of G. mangostana peel on the histology, immunohistochemistry, and biochemistry of thioacetamide (TAA) induced liver cirrhosis in Sprague Drawly (SD)
rats. The rats were distinctly administered with two doses of G. mangostana (250 mg/kg and 500 mg/kg) with
TAA showed a significant reduction in liver index and hepatocyte proliferation with much lesser cell damage.
These groups were significantly down-regulated the PCNA, α-SMA, and TGF-β1. The liver homogenate exhibited
increased antioxidant enzymes (SOD and CAT) activities accompanied with decline in malondialdehyde (MDA)
level. The serum level of bilirubin, total protein, albumin and liver enzymes (ALP, ALT, and AST) were restored
to normal and were comparable to that normal control and silymarin with TAA treated groups. Thus normal
microanatomy of hepatocytes, suppression of PCNA, α-SMA, TGF-β, improved antioxidant enzymes, reduced
MDA with restoration of liver biomarkers demonstrates hepatoprotective influence of G. mangostana.

Item Type: Article
Uncontrolled Keywords: Traditional Therapy; Garcinia Mangostana; Thioacetamide; Liver cirrhosis; Hepatoprotective Effect
Subjects: Q Science > Q Science (General)
Divisions: Department of General Biology > Research papers
Depositing User: ePrints Depositor
Date Deposited: 03 Oct 2024 13:01
Last Modified: 03 Oct 2024 13:01
URI: https://eprints.cihanuniversity.edu.iq/id/eprint/1409

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